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Biological Labeling and Fluorescence Imaging using Quantum Dots
Synthesis, Spectroscopy, Blinking and Interfacial Chemistry of Quantum Dots (Funded by NSF)

 
Single Molecule FRET to study Protein Structure, Dynamics and Function (Funded by DOE)

 

 

Figure from Mandal et al (2013) Chem. Commun., 49, 624-626.
Abstract Image

Figure From Gao et al (2017) ACS Nano. ASAP Article

 

Abstract Image Figure from Omogo et al. (2016) ACS Nano, 10, 4072-4082.

 

Thumbnail image of graphical abstract

 

Figure from Bajwa et al. (2016) ChemPhysChem, 17, 731-740.

 

 
http://www.cell.com/cms/attachment/2076825403/2070504685/cover.tif.jpg
Cover picture from Henderson et al (2016) Biophys. J. 111, 1151-1162

 

 

Figure from Gao et al (2015) J. Biol. Chem., 290, 15462-15474

 

Publications of Prof. Colin D Heyes

Click on links to go to the electronic resource (Subscription to Journal will be required).

Please e-mail me if you need reprints.

 

[1]   Ramesh Vasan, Feng Gao, M. Omar Mansareh and Colin D. Heyes. Investigation of charge transport between nickel oxide nanoparticles and CdSe/ZnS alloyed nanocrystals. (2017) MRS Advances, 2, 2935-2941.

[2]   Feng Gao, Pooja Bajwa, Anh Nguyen, and Colin D. Heyes. Shell-Dependent Photoluminescence Studies Provide Mechanistic Insights into the Off-Grey-On Transitions of Blinking Quantum Dots. (2017) ACS Nano. 11, 2905-2916.

[3]   Rory C. Henderson, Feng Gao, Srinivas Jayanthi, Alicia Kight, Priyanka Sharma, Robyn L. Goforth, Colin D. Heyes, Ralph L. Henry, T.K.S. Kumar. Domain Organization in the 54-kDa Subunit of the Chloroplast Signal Recognition Particle. (2016) Biophys. J. (cover article). 111, 1151-1162

[4]   Benard Omogo, Feng Gao, Pooja Bajwa, Mizuho Kaneko and Colin D. Heyes. Reducing Blinking in Small Core-Multishell Quantum Dots by Carefully Balancing Confinement Potential and Induced Lattice Strain: The “Goldilocks” Effect. (2016) ACS Nano 10, 4072-4082

[5]   Pooja Bajwa, Feng Gao, Anh Nguyen, Benard Omogo and Colin D. Heyes. Influence of the Inner Shell Architecture on Quantum Yield and Blinking Dynamics in Core/Multi-Shell Quantum Dots. (2016) ChemPhysChem. 17, 731-740

[6]   Kyla M. Morris, Rory Henderson, Thallapuranam Krishnaswamy Suresh Kumar, Colin D. Heyes, and Paul D. Adams. Intrinsic GTP Hydrolysis is Observed For a Switch 1 Variant of Cdc42 in the Presence of a Specific GTPase Inhibitor. (2016) Small GTPases 7, 1-11

[7]   Samir V Jenkins, Avinash Srivatsan, Kimberly Y Reynolds, Feng Gao, Yongbin Zhang, Colin D Heyes, Ravindra K Pandey, Jingyi Chen. Understanding the interactions between porphyrin-containing photosensitizers and polymer-coated nanoparticles in model biological environments. (2015) J. Coll. Int. Sci. 461, 225-231

[8]   Feng Gao, Alicia D. Kight, Rory Henderson, Srinivas Jayanthi, Parth Patel, Marissa Murchison, Priyanka Sharma, Robyn L. Goforth, T.K.S. Kumar, Ralph L. Henry, and Colin D. Heyes. Regulation of Structural Dynamics within a Signal Recognition Particle Promotes Binding of Protein Targeting Substrates (2015) J. Biol. Chem. 290, 15462-15474

[9]   Marion G. Götz, Hiroko Takeuchi, Matthew J. Goldfogel, Julia M. Warren, Brandon D. Fennell, and Colin D. Heyes. Visible-Light Photocatalyzed Cross-Linking of Diacetylene Ligands by Quantum Dots to Improve Their Aqueous Colloidal Stability. (2014) J. Phys Chem B. 118, 14103-14109

[10] Hiroko Takeuchi, Benard Omogo, and Colin D Heyes. Are Bidentate Ligands Really Better than Monodentate Ligands For Nanoparticles? (2013) Nano Lett. 13, 4746-4752.

[11] Feng Gao , Adam Kreidermacher , Ingrid Fritsch , and Colin D Heyes. 3D Imaging of Flow Patterns in an Internally-Pumped Microfluidic Device: Redox Magnetohydrodynamics and Electrochemically-Generated Density Gradients. (2013) Anal. Chem. 85, 4414-4422.

[12] Benard Omogo, Jose F. Aldana and Colin D. Heyes, Radiative and Non-Radiative Lifetime Engineering of Quantum Dots in Multiple Solvents by Surface Atom Stoichiometry and Ligands. (2013) J. Phys. Chem. C. 117, 2317-2327.

[13] Gopa Mandal, Molly Darragh, Y. Andrew Wang, and Colin D. Heyes. Cadmium-Free Quantum Dots as Time-Gated Bioimaging Probes in Highly-Autofluorescent Human Breast Cancer Cells. (2013) Chem. Commun. 49, 624-626.

[14] Nela Durisic, Antoine G. Godin, Claudia M. Wever, Colin D. Heyes, Melike Lakadamyali, and Joseph A. Dent. Stoichiometry of the Human Glycine Receptor Revealed by Direct Subunit Counting. (2012) J. Neurosci. 32, 12915-12920

[15] Nela Durisic, Antoine G. Godin, Derrel Walters, Peter Grütter, Paul W. Wiseman and Colin D. Heyes. Probing the “Dark" Fraction of Core–Shell Quantum Dots by Ensemble and Single Particle pH-Dependent Spectroscopy. (2011) ACS Nano, 5, 9062-9073

[16] Nela Durisic, Paul W. Wiseman, Peter Grütter and Colin D. Heyes. A Common Mechanism Underlies the Dark Fraction Formation and Fluorescence Blinking of Quantum Dots. (2009) ACS Nano, 3, 1167-1175

[17] Vladimir V Breus, Colin D. Heyes, Kyrylo Tron and G. Ulrich Nienhaus. Zwitterionic Biocompatible Quantum Dots for Wide pH Stability and Weak Non-Specific Binding to Cells. (2009). ACS Nano. 3, 2573-2580

[18] Rafael Khatchadourian, Alexia Bachir, Samuel J. Clarke, Colin D. Heyes, Paul W. Wiseman, and Jay L. Nadeau. Fluorescence intensity and intermittency as tools for tracking bioconjugate processing in living cells. (2007). J. Biomed. Biotech. 40145

[19] Vladimir V. Breus, Colin D. Heyes and G. Ulrich Nienhaus. Quenching of CdSe-ZnS Core-Shell Quantum Dot Luminescence by Water-Soluble Thiolated Ligands. (2007) J. Phys. Chem. C. 111, 18589-18594

[20] Paul De Koninck, Simon Labrecque, Colin D. Heyes, and Paul W. Wiseman. Probing synaptic signaling with quantum dots. (2007). HFSP Journal. 1, 5-10

[21] Colin D. Heyes, Andrei Yu. Kobitski, Vladimir V. Breus and G. Ulrich Nienhaus. Effect of the Shell on Blinking Statistics in Single Core-Shell Quantum Dots. (2007). Phys. Rev. B. 75, 125431

[22] Colin D. Heyes, Jürgen Groll, Martin Moeller and G. Ulrich Nienhaus. Synthesis, Patterning and Applications of Star-shaped Poly(ethylene glycol) Biofunctionalized Surfaces. (2007). Mol. Biosystems. 3, 419-430

[23] Colin D. Heyes and G. Ulrich Nienhaus. Ultrasensitive Fluorescence Microscopy Studies of Protein Interactions with Functionalized Surfaces. (2007). Z. Phys. Chem. 221, 75-93.

[24] R. J. Owen, C. D. Heyes, D. Knebel, C. Röcker, G.U. Nienhaus. An Integrated Instrumental Setup for the Combination of Atomic Force Microscopy with Optical Spectroscopy. (2006). Biopolymers, 82, 410-414.

[25] Elza V. Kuzmenkina, Colin D. Heyes and G. Ulrich Nienhaus. Single Molecule FRET Study of Denaturant Induced Unfolding of RNase H. (2006). J. Mol. Biol., 357, 313-324.

[26] Elza V. Kuzmenkina, Colin D. Heyes and G. Ulrich Nienhaus. Single Molecule FRET study of Protein Dynamics under Denaturing Conditions. (2005). Proc. Natl. Acad. Sci., 102, 15471-15476.

[27] Andrei Yu. Kobitski, Colin D. Heyes and G. Ulrich Nienhaus. Total Internal Reflection Fluorescence Microscopy - A Powerful Tool to Study Single Quantum Dots. (2004) App. Surf. Sci., 234, 86-92.

[28] Elza Amirgoulova, Jürgen Groll, Colin D. Heyes, Thomas Ameringer, Carlheinz Röcker, Martin Möller and G. Ulrich Nienhaus. Biofunctionalized Polymer Surfaces Exhibiting Minimal Interaction Towards Immobilized Proteins. (2004). ChemPhysChem., 5, 552-555.

[29] Jürgen Groll , Elza Amirgoulova, Thomas Ameringer, Colin D. Heyes, Carlheinz Röcker, Martin Möller and G. Ulrich Nienhaus. Biofunctionlaized Ultrathin Coatings of Cross-linked Star-shaped Poly(ethylene oxide) allow reversible folding of single immobilized RNase H molecules. (2004). J. Am. Chem. Soc., 126, 4234-4239

[30] Colin D. Heyes, Andrei Yu. Kobitski, Elza V. Amirogoulova and G. Ulrich Nienhaus. Biocompatible Surfaces for Specific Tethering of Single Protein Molecules. (2004). J. Phys. Chem. B., 108, 13387-13394.

[31] R.M. Donlan, J.A. Piede, C.D. Heyes, L. Sanii, R. Murga, P. Edmonds, I. El-Sayed and M.A. El-Sayed. A Model System for Growing and Quantifying Streptococcus pneumoniae Biofilms in Situ and in Real Time. (2004). App. Env. Microbiol., 70, 4980-4988.

[32] Colin D. Heyes, Keith B. Reynolds and Mostafa A. El-Sayed. Eu3+ Binding to Europium-Regenerated Bacteriorhodopsin upon Delipidation and Monomerization. (2004) FEBS Lett., 562, 207-210

[33] Colin D. Heyes and Mostafa A. El-Sayed. Proton Transfer Reactions in Native and Deionized Bacteriorhodopsin upon Delipidation and Monomerization. (2003) Biophys. J., 85, 426-434.

[34] Colin D. Heyes and Mostafa A. El-Sayed. Thermal Properties of Bacteriorhodopsin. (2003) J. Phys. Chem. B., Feature Article. 107, 12045-12053.

[35] Colin D. Heyes and Mostafa A. El-Sayed. The Role of the Native Lipids and Lattice Structure in Bacteriorhodopsin Protein Conformation and Stability as Studied by Temperature Dependent FT-IR. (2002) J. Biol. Chem., 277, 29437-29443.

[36] Colin D. Heyes, Jianping Wang, Laurie S. Sanii and Mostafa A. El-Sayed. Fourier Transform Infrared Spectroscopy Study of the Effect of Different Cations on Bacteriorhodopsin Protein Thermal Stability. (2002) Biophys. J., 82, 1598-1606.

[37] Jianping Wang, Colin D. Heyes and Mostafa A. El-Sayed. Refolding of Thermal Denatured Bacteriorhodopsin in Purple Membrane. (2002) J. Phys. Chem. B, 106, 723-729.

[38] Jianping Wang, Stephan Link, Colin D. Heyes and Mostafa A. El-Sayed. Comparison of the Dynamics of the Primary Events of Bacteriorhodopsin in its Trimeric and Monomeric States. (2002) Biophys. J, 83, 1557-1566.

[39] Colin D. Heyes and Mostafa A. El-Sayed. Effect of Temperature, pH, and Metal Ion Binding on the Secondary Structure of Bacteriorhodopsin: FT-IR Study of the Melting and Premelting Transition Temperatures. (2001) Biochemistry, 40, 11819-11827.

 

 

 

 

 

 

Last Update: Mar 7th 2018